Evolution of four BK virus subtypes

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Evolution of four BK virus subtypes.

BK viruses (BKV) comprise four subtypes that are distinguishable by serological and molecular methods with the latter indicating up to four subgroups within subtype I. In this study, the phylogeny of all BKV subtypes was analyzed. Phylogenetic analyses of the viral structural protein VP1, concatenated sequences including the T-Ag, t-Ag, VP1 and VP2 genes and the entire coding region of BKV, eac...

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The BK virus a member of the Polyomaviruses family was first isolated from the urine of the kidney recipient. Infection with this virus and infection usually occurs in childhood (5-9 years) but most of the time (90%) of sera are positive and without symptoms. Polyomaviruses including the BK virus have also been suggested to be a contributing factor to some cancers in humans such as brain tumors...

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Vertical transmission of BK virus in pregnancy: A narrative review

Background: Primary infection with the BK virus occurs in the tonsils and is transmitted to other tissues and organs, especially the kidneys, by infecting monocytes. Infection with this virus is rarely associated with clinical disease but reactivating the virus in people who have a suppressed immune system can cause kidney or bladder damage. Due to the importance of activating the BK virus in s...

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Monitoring subtypes of the human polyomavirus BK in Iranian adult kidney transplant patients

BK virus (BKV) is a polyomavirus with seroprevalence in adults, ranging from 60 to 100%. It is considered as usual cause of renal dysfunction after the allograft renal transplantation nephropathy. Potent immunosuppressive therapy in kidney transplantation can lower the rate of acute rejection. Therefore, untreated BKV infections lead to kidney allograft dysfunction or loss. In order to estimate...

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[BK-virus-associated Nephropathy].

The infection by the BK Polyomavirus (BKV) is an emerging problem in kidney transplants that contributes to a chronic loss of kidney grafts, and in which immunosuppression plays a decisive role. Understanding its risk factors and strictly monitoring urine and serological markers of the infection could mitigate the undesirable effects of this disease. In this review, we investigate the clinical ...

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ژورنال

عنوان ژورنال: Infection, Genetics and Evolution

سال: 2008

ISSN: 1567-1348

DOI: 10.1016/j.meegid.2008.05.006